Renal involvment is the most common clnical problem in amyloidosis, affecting more than one third of the patients at presentation, and renal amyloidosis accounts for 3~9% of nephrotic syndrome in adults. However, there were several case reports
in
Korea.
We retrospectively analyzed the clinical and laboratory data of 17 patients with biopsyproved renal amyloidosis examined at Seoul National University Hospital. And the results were as follows;
1) The underlying diseases of renal amylodiosis were multiple myeloma (5 patients), Castleman's disease (1 patient), and ankylosing spondylitis (1 patient). The underlying disease of 10 patients could not be found.
2) 12 patients (71%) were over age of 50 years at diagnosis.
3) The renal manifestations were nephrotic syndrome (11 patients), chroinc nephritic syndrome (5 patients), and asymptomatic urinary abnormality (1 patient).
4) A monoclonal protein was found n 10 patients (59%). The lambda to kappa ratio was 9:1.
5) The median survival of patients with renal amyloidosis was 14 months.
These findings suggest that amyloidosis should be considered in nephrotic syndrome over age of 50 vears.
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